On August 31, 1990, Ferrarini, P. L.; Mori, C.; Primofiore, G.; Da Settimo, A.; Breschi, M. C.; Martinotti, E.; Nieri, P.; Ciucci, M. A. published an article.Related Products of 76629-10-2 The title of the article was Synthesis and β-blocking activity of (E)- and (Z)-iminoethers of 1,8-naphthyridine. Potential antihypertensive agents. 4. And the article contained the following:
A series of (E)- (I, R = Br, Cl, Me, OMe or OEt, R1 = H or Br; R2 = iso-Pr, tert-Bu) and (Z)-imino ethers (II, R = Br, Cl, Me, OMe or OEt and R2 = iso-Pr or tert-Bu) of 1,8-naphthyridine were prepared from the corresponding ketones by a series of reactions involving oxime formation, reaction with epichlorohydrin followed by reaction with amines. The pharmacol. activities of these compounds were evaluated by using isolated guinea pig atria or trachea, or rat vas deferens. All compounds showed β2 adrenergic agonist and B1-blocking properties. Neither stimulation nor blocking activity was observed on α receptors. The activity was independent of the side-chain and no difference was observed in activity between (E)-I or (Z)-II. The experimental process involved the reaction of 7-Chloro-2,3-dihydro-1,8-naphthyridin-4(1H)-one(cas: 76629-10-2).Related Products of 76629-10-2
The Article related to beta blocker naphthyridine imino ether preparation, adrenergic agonist naphthyridine imino ether preparation, naphthyridine imino ether adrenergic agonist antagonist, antihypertensive naphthyridine imino ether and other aspects.Related Products of 76629-10-2
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem