On May 11, 2018, Cheng, Zhanling; Wang, Jianhua; Wang, Min; Yang, Song published a patent.Synthetic Route of 869640-41-5 The title of the patent was Preparation of tetrahydroisoquinoline derivatives for use as anti-hepatitis b virus agents. And the patent contained the following:
Title compounds I [R1 and R2 independently = H, amino, alkoxy, cycloalkoxy, etc.; R3 = H, alkyl, or cycloalkyl; U = N, C(alkoxy), C(alkyl), etc.; V = H, N, C(alkyl), or C(cycloalkyl); W, X, and Y independently = N or CH], and their pharmaceutically acceptable salts, are prepared and disclosed as anti-hepatitis b virus agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in HBsAg inhibition assays, e.g., II demonstrated an IC50 value of 3.172 μM. The experimental process involved the reaction of 7-Benzyl-5,6,7,8-tetrahydro-1,7-naphthyridin-2(1H)-one(cas: 869640-41-5).Synthetic Route of 869640-41-5
The Article related to tetrahydroisoquinoline preparation antihepatitis b virus agent, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Synthetic Route of 869640-41-5
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem