Mosaddeghi, Pouria; Eslami, Mahboobeh; Farahmandnejad, Mitra; Akhavein, Mahshad; Ranjbarfarrokhi, Ratin; Khorraminejad-Shirazi, Mohammadhossein; Shahabinezhad, Farbod; Taghipour, Mohammadjavad; Dorvash, Mohammadreza; Sakhteman, Amirhossein; Zarshenas, Mohammad M.; Nezafat, Navid; Mobasheri, Meysam; Ghasemi, Younes published the artcile< A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants>, HPLC of Formula: 1223001-51-1, the main research area is autophagy systems pharmacol medicinal plant Persia.
Abstract: Identifying the nature of this correlation and treatment of age-related diseases has been a major subject of both modern and traditional medicine. Traditional Persian Medicine (TPM) embodies many prescriptions for the treatment of ARDs. Given that autophagy plays a critical role in antiaging processes, the present study aimed to examine whether the documented effect of plants used in TPM might be relevant to the induction of autophagy. To this end, the TPM-based medicinal herbs used in the treatment of the ARDs were identified from modern and traditional references The known phytochems. of these plants were then examined against literature for evidence of having autophagy inducing effects. As a result, several plants were identified to have multiple active ingredients, which indeed regulate the autophagy or its upstream pathways. In addition, gene set enrichment anal. of the identified targets confirmed the collective contribution of the identified targets in autophagy regulating processes. Also, the protein-protein interaction (PPI) network of the targets was reconstructed. Network centrality anal. of the PPI network identified mTOR as the key network hub. Given the well-documented role of mTOR in inhibiting autophagy, our results hence support the hypothesis that the antiaging mechanism of TPM-based medicines might involve autophagy induction.
Scientific Reports published new progress about Acute respiratory distress syndrome. 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, HPLC of Formula: 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem