Kosowicz, John G.; Lee, Jaeyeun; Peiffer, Brandon; Guo, Zufeng; Chen, Jianmeng; Liao, Gangling; Hayward, S. Diane; Liu, Jun O.; Ambinder, Richard F. published the artcile< Drug modulators of b cell signaling pathways and epstein-barr virus lytic activation>, Electric Literature of 1223001-51-1, the main research area is herpesvirus 4 activation b cell signaling pathway drug modulator; B cell receptor pathway; Epstein-Barr virus; cyclosporine; dasatinib; ibrutinib; idelalisib; lytic infection; mTOR; rapamycin; tacrolimus.
Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus that establishes a latency reservoir in B cells. In this work, we show that ibrutinib, idelalisib, and dasatinib, drugs that block B cell receptor (BCR) signaling and are used in the treatment of hematol. malignancies, block BCR-mediated lytic induction at clin. relevant doses. We confirm that the immunosuppressive drugs cyclosporine and tacrolimus also inhibit BCR-mediated lytic induction but find that rapamycin does not inhibit BCR-mediated lytic induction. Further investigation shows that mammalian target of rapamycin complex 2 (mTORC2) contributes to BCR-mediated lytic induction and that FK506-binding protein 12 (FKBP12) binding alone is not adequate to block activation. Finally, we show that BCR signaling can activate EBV lytic induction in freshly isolated B cells from peripheral blood mononuclear cells (PBMCs) and that activation can be inhibited by ibrutinib or idelalisib.
Journal of Virology published new progress about Antiviral agents. 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, Electric Literature of 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem