Almstedt, Elin; Elgendy, Ramy; Hekmati, Neda; Rosen, Emil; Waern, Caroline; Olsen, Thale Kristin; Dyberg, Cecilia; Doroszko, Milena; Larsson, Ida; Sundstroem, Anders; Arsenian Henriksson, Marie; Paahlman, Sven; Bexell, Daniel; Vanlandewijck, Michael; Kogner, Per; Joernsten, Rebecka; Krona, Cecilia; Nelander, Sven published the artcile< Integrative discovery of treatments for high-risk neuroblastoma>, Product Details of C24H15F3N4O, the main research area is neuroblastoma CNR2 MAPK8 Target Translator algorithm.
Despite advances in the mol. exploration of paediatric cancers, approx. 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with exptl. evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumor biobanks, pharmacol. databases, and cellular networks to predict how targeted interventions affect mRNA signatures associated with high patient risk or disease processes. We find more than 80 targets to be associated with neuroblastoma risk and differentiation signatures. Selected targets are evaluated in cell lines derived from high-risk patients to demonstrate reversal of risk signatures and malignant phenotypes. Using neuroblastoma xenograft models, we establish CNR2 and MAPK8 as promising candidates for the treatment of high-risk neuroblastoma. We expect that our method, available as a public tool (targettranslator.org), will enhance and expedite the discovery of risk-associated targets for paediatric and adult cancers.
Nature Communications published new progress about Apoptosis. 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, Product Details of C24H15F3N4O.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem