Li, Hao; Sun, Wei; Huang, Xiuli; Lu, Xiao; Patel, Paresma R.; Kim, Myunghoon; Orr, Meghan J.; Fisher, Richard M.; Tanaka, Takeshi Q.; McKew, John C.; Simeonov, Anton; Sanderson, Philip E.; Zheng, Wei; Williamson, Kim C.; Huang, Wenwei published the artcile< Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities>, HPLC of Formula: 1223001-51-1, the main research area is benzonaphthyridinone preparation antimalarial SAR bromochloroquinolinylacrylate tandem reaction aniline boronate; Torin; benzo[h][1,6]naphthyridin-2(1H)-ones; gametocytocidal activity; malaria; one-pot reaction; quinoline.
A novel three-component, two-step, 1-pot nucleophilic aromatic substitution (SNAr)-intramol. cyclization-Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). On the basis of the new efficiently convergent synthetic route, a library of Torin 2 analogs was synthesized. The antimalarial activities of these compounds were evaluated against asexual parasites using a growth inhibition assay and gametocytes using a viability assay.
ACS Combinatorial Science published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, HPLC of Formula: 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem