Chernoryzh, Ya. Yu.; Fedorova, N. E.; Yurlov, K. I.; Simonov, R. A.; Kornev, A. B.; Karpov, D. S.; Zakirova, N. F.; Ivanov, A. V.; Kushch, A. A.; Gintsburg, A. L. published the artcile< Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway>, Computed Properties of 1223001-51-1, the main research area is doxorubicin anticancer agent antibiotic PI3K cytomegalovirus leukemia.
Abstract: Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Mol. targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined
Doklady Biochemistry and Biophysics published new progress about Antibiotics Role: THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, Computed Properties of 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem