Bein, Kiflai; Ganguly, Koustav; Martin, Timothy M.; Concel, Vincent J.; Brant, Kelly A.; Di, Y. P. Peter; Upadhyay, Swapna; Fabisiak, James P.; Vuga, Louis J.; Kaminski, Naftali; Kostem, Emrah; Eskin, Eleazar; Prows, Daniel R.; Jang, Ann-Soo; Leikauf, George D. published the artcile< Genetic determinants of ammonia-induced acute lung injury in mice>, HPLC of Formula: 1223001-51-1, the main research area is genetic determinant ammonia acute lung injury mice; ARDS; acute lung injury; chemical threat; functional genomics; transcriptomics.
In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic anal. was used to help resolve the genetic determinants of ammonia-induced acute lung injury. The encoded proteins were prioritized based on mol. function, nonsynonymous SNP within a functional domain or SNP within the promoter region that altered expression. This integrative functional approach revealed 14 candidate genes that included Aatf, Avil, Cep162, Hrh4, Lama3, Plcb4, and Ube2cbp, which had significant SNP associations, and Aff1, Bcar3, Cntn4, Kcnq5, Prdm10, Ptcd3, and Snx19, which had suggestive SNP associations Of these genes, Bcar3, Cep162, Hrh4, Kcnq5, and Lama3 are particularly noteworthy and had pathophysiol. roles that could be associated with acute lung injury in several ways.
American Journal of Physiology published new progress about Actins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1223001-51-1 belongs to class naphthyridine, and the molecular formula is C24H15F3N4O, HPLC of Formula: 1223001-51-1.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem