Vinoth, M.; Natarajan, B.; Sundaram, C. Shanmuga published the artcile< Characterization and evaluation ethyl acetate extract of melochia corchorifolia leaf-anticancer antibiological and molecular docking studies on breast cancer estrogen receptor>, Reference of 6882-68-4, the main research area is Melochia leaf extract anticancer antibiol breast cancer estrogen receptor.
The present work focused on Phytochem. screening, characterization, anticancer activity and antibiol. activity of Et acetate extract of Melochia corchorifolia leaves followed by mol. docking studies have been carried out. The plant leaves have been collected, weighed, and extracted with the soxhlet apparatus by using Et acetate solvent and then extracted are subjected to phytochem. screening. Antibiol. activity of plant leaves Et acetate extract has been tested against six bacterial and two fungal strains using agar well diffusion methodol. The characterization of phytoconstituents compounds has been carried out using various spectroscopy method such as GC-MS (Gas chromatog. Mass spectroscopy), UV-visible and Fourier-transform IR. Auto dock tool (4.2.0) is used for mol. docking studies. The phytochem. anal. of Melochia corchorifolia Et acetate leaves, reveals the existence of carbohydrates, glycosides, triterpenes flavonoids and alkaloids. Antimicrobial activity is effective against gram-pos. bacterial strains namely Staphylococcus aureus (17 mm), Bacillus subtilis (16 mm), the gram-neg. bacterial strains namely Salmonella typhi (15 mm) and E. coli (14 mm). Moreover, the extract is also found to be effective against Aspergillus Niger (18 mm) fungal species. The GC-MS and FT-IR anal. show bioactive compounds and their functional groups. UV-VIS anal. results reveal that the presence of phytoconstituents derivatives in the range between 206-350 nm. The cytotoxicity activity for the MCF-7 cell line shows that the drug efficacy IC50 value is 148.836 (μg/mL). Further, the predicted bioactive compounds are docked with the cancer estrogen protein receptor (PDB ID: 3s7s) with ligand martidin-15 one shows the highest binding affinity. The study reveals the potential of Melochia corchorifolia leaves Et acetate extract showed antibiol. and anticancer activity.
Indian Journal of Chemical Technology published new progress about Affinity (Binding). 6882-68-4 belongs to class naphthyridine, and the molecular formula is C15H24N2O, Reference of 6882-68-4.
Referemce:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem