The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ) is researched.HPLC of Formula: 2689-65-8.Wang, Peng; Farmer, Marcus E.; Yu, Jin-Quan published the article 《Ligand-Promoted meta-C-H Functionalization of Benzylamines》 about this compound( cas:2689-65-8 ) in Angewandte Chemie, International Edition. Keywords: ligand promoted meta CH functionalization benzylamine; amination; benzylamines; chlorination; meta-C−H arylation; pyridone ligand. Let’s learn more about this compound (cas:2689-65-8).
Meta-C-H functionalization of benzylamines has been developed using a PdII/transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.
After consulting a lot of data, we found that this compound(2689-65-8)HPLC of Formula: 2689-65-8 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem