The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Iodo-2-furaldehyde( cas:2689-65-8 ) is researched.Name: 5-Iodo-2-furaldehyde.Wu, Qing-Feng; Shen, Peng-Xiang; He, Jian; Wang, Xiao-Bing; Zhang, Forrest; Shao, Qian; Zhu, Ru-Yi; Mapelli, Claudio; Qiao, Jennifer X.; Poss, Michael A.; Yu, Jin-Quan published the article 《Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation》 about this compound( cas:2689-65-8 ) in Science (Washington, DC, United States). Keywords: enantioselective arylation alkenylation alkynylation isobutyric acid amide organic iodide. Let’s learn more about this compound (cas:2689-65-8).
The enzymic β-C-H hydroxylation of the feedstock chem. isobutyric acid has enabled the asym. synthesis of a wide variety of polyketides. The analogous transition metal-catalyzed enantioselective β-C-H functionalization of isobutyric acid-derived substrates should provide a versatile method for constructing useful building blocks with enantioenriched α-chiral centers from this abundant C-4 skeleton. However, the desymmetrization of ubiquitous iso-Pr moieties by organometallic catalysts has remained an unanswered challenge. Herein, the authors report the design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of iso-Pr groups via palladium insertion into the C(sp3)-H bonds of one of the prochiral Me groups. We detail the enantioselective β-arylation, -alkenylation, and -alkynylation of isobutyric acid/2-aminoisobutyric acid derivatives, which may serve as a platform for the construction of α-chiral centers.
From this literature《Formation of α-chiral centers by asymmetric β-C(sp3)-H arylation, alkenylation, and alkynylation》,we know some information about this compound(2689-65-8)Name: 5-Iodo-2-furaldehyde, but this is not all information, there are many literatures related to this compound(2689-65-8).
Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem