In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors, published in 2004-08-26, which mentions a compound: 1569-17-1, mainly applied to aminothiazole naphthyridine preparation transforming growth factor receptor inhibitor; aminopyrazole naphthyridine preparation transforming growth factor receptor inhibitor; naphthyridinylaminothiazole preparation transforming growth factor alk5 autophosphorylation inhibitor; naphthyridine preparation transforming growth factor inhibitor structure activity relationship, Product Details of 1569-17-1.
Optimization of the screening hit I led to the identification of novel 1,5-naphthyridine aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the transforming growth factor-β type I receptor, ALK5. Compounds II and III, which inhibited ALK5 autophosphorylation with IC50 = 6 and 4 nM, resp., showed potent activities in both binding and cellular assays and exhibited selectivity over p38 mitogen-activated protein kinase. The X-ray crystal structure of III in complex with human ALK5 is described, confirming the binding mode proposed from docking studies.
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem