Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Iodo-2-furaldehyde, is researched, Molecular C5H3IO2, CAS is 2689-65-8, about Synthesis based on formylfuro(2,3-b) benzothiachromone.Safety of 5-Iodo-2-furaldehyde.
ο[(5-Formyl-2-furyl)thio]-benzoic acid, obtained from reaction of ο-mercaptobenzoic acid with 5-iodofurfural, cyclized (polyphosphoric acid) to give the furobenzothiachromone I (R = CHO), which when treated with HONH2 gave I (R = CH:NOH). The latter was converted (Ac2O) to the nitrile I (R = CN), hydrolysis (polyphosphoric acid) of which gave the expected amide I (R = CONH2).
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Reference:
1,8-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N2 – PubChem