Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. Application In Synthesis of Dibenzo[b,d]furan, The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 132-64-9, Name is Dibenzo[b,d]furan, SMILES is C12=CC=CC=C1C3=CC=CC=C3O2, belongs to naphthyridine compound. In a article, author is Dhamodharan, V., introduce new discover of the category.
Various biologically relevant G-quadruplex DNA structures offer a platform for therapeutic intervention for altering the gene expression or by halting the function of proteins associated with telomeres. One of the prominent strategies to explore the therapeutic potential of quadruplex DNA structures is by stabilizing them with small molecule ligands. Here we report the synthesis of bisquinolinium and bispyridinium derivatives of 1,8-naphthyridine and their interaction with human telomeric DNA and promoter G-quadruplex forming DNAs. The interactions of ligands with quadruplex forming DNAs were studied by various biophysical, biochemical, and computational methods. Results indicated that bisquinolinium ligands bind tightly and selectively to quadruplex DNAs at low ligand concentration (similar to 0.2-0.4 mu M). Furthermore, thermal melting studies revealed that ligands imparted higher stabilization for quadruplex DNA (an increase in the T-m of up to 21 degrees C for human telomeric G-quadruplex DNA and >25 degrees C for promoter G-quadruplex DNAs) than duplex DNA (Delta T-m < 1.6 degrees C). Molecular dynamics simulations revealed that the end-stacking binding mode was favored for ligands with low binding free energy. Taken together, the results indicate that the naphthyridine-based ligands with quinolinium and pyridinium side chains form a promising class of quadruplex DNA stabilizing agents having high selectivity for quadruplex DNA structures over duplex DNA structures. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, their interactions with reaction intermediates and transition states. I hope my blog about 132-64-9 is helpful to your research. Application In Synthesis of Dibenzo[b,d]furan.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem