As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 1588-83-6, Name is 4-Amino-3-nitrobenzoic acid, molecular formula is , belongs to naphthyridine compound. In a document, author is Huang, Shengdian, COA of Formula: https://www.ambeed.com/products/1588-83-6.html.
RO8191 represents a newly identified small-molecule IFN-alpha-substitute, which displays potent anti-HCV activity. In this communication, we reported the design and synthesis of two series of imidazo[1,2-alpha][1,8]naphthyridine derivatives, as RO8191 analogues, via a direct C-H arylation approach. Notably, by adjusting the reaction conditions, we could achieve the two series of analogues via regioselective single-and double-arylations, respectively. The anti-HCV activities of the synthesized compounds were evaluated within the HCV cell culture system, and the preliminary results showed that some of them displayed promising anti-HCV activities.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. I hope my blog about 1588-83-6 is helpful to your research. COA of Formula: https://www.ambeed.com/products/1588-83-6.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem