In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 99-09-2, Name is 3-Nitroaniline, SMILES is NC1=CC=CC([N+]([O-])=O)=C1, belongs to naphthyridine compound. In a document, author is Gopalsamy, Ariamala, introduce the new discover, SDS of cas: 99-09-2.
The dibenzo[c,f]-2,7-naphthyridine ring system was found to be of biological interest, but had limited synthetic accessibility. The initial compound of interest, 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine, was obtained in < 25% yield by reacting 4-chloro-6,7-dimethoxy-quinoline-3-carbonitrile with 2-methyl-benzene-1,3-diamine. A reliable high-yielding procedure was identified through the use of design of experiments (DOE). The effects of stoichiometry of reagents, catalyst, and temperature were explored in this study. The DOE optimization suggested temperatures higher than the boiling point of our solvent. Hence, microwave heating was used, resulting in 80% yield of the desired product. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 99-09-2. SDS of cas: 99-09-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem