Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. , Recommanded Product: 3-Chlorophenylboronic acid, 63503-60-6, Name is 3-Chlorophenylboronic acid, molecular formula is C6H6BClO2, belongs to naphthyridine compound. In a document, author is Meredith, Erik L., introduce the new discover.
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy. As PKC was previously identified as the immediate upstream activator of PKD, PKD vs PKC selectivity was essential to understand the effect of PKD inhibition in models of cardiac hypertrophy and heart failure. The present study describes the modification of the HTS hit to a series of prototype pan-PKD inhibitors with routine 1000-fold PKD vs PKC selectivity. Example compounds inhibited PKD activity in vitro, in cells, and in vivo following oral administration. Their effects on heart morphology and function are discussed herein.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 63503-60-6, in my other articles. Recommanded Product: 3-Chlorophenylboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem