Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 126-30-7, Name is 2,2-Dimethylpropane-1,3-diol, molecular formula is C5H12O2, Category: naphthyridines, SMILES is OCC(C)(C)CO belongs to naphthyridine compound, is a common compound. In a patnet, author is Chen Xiu-Wen, once mentioned the new application about 126-30-7.
title compound (14S)-2,14-diphenyl-6,6a,11,12-tetrahydro-5H,10H,14H-[1,8]naphthyridino[1,2-c]pyrido[3,2,1-ij]quinazoline-3-carbonitrile (C31H26N4, M-r = 454.56) has been synthesized with 2-aminonicotinaldehyde and 3-oxo-3-phenylpropanenitrile as starting materials, and its crystal structure was determined by single-crystal X-ray diffraction for the first time. The crystal belongs to the triclinic system, space group P (1) over bar with a = 8.5833(8), b = 11.9168(12), c = 14.4424(14) angstrom, alpha = 84.208(3)degrees, beta = 88.427(3)degrees, gamma = 73.704(3)degrees, V= 1410.7(2) angstrom(3), Z = 2, F(000) = 480, mu = 0.064 mm(-1), S = 0.966, the final R = 0.0484 and wR = 0.1388 for 5041 observed reflections with I > 2 sigma (I) and 316 variable parameters. The preliminary biological tests show that the title compound has a good antitumor activity against K562 in vitro.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem