Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 573-17-1, Name is 9-Bromophenanthrene, molecular formula is C14H9Br, Safety of 9-Bromophenanthrene, belongs to naphthyridine compound, is a common compound. In a patnet, author is Naik, Tangali R. Ravikumar, once mentioned the new application about 573-17-1.
The microwave-enhanced synthesis of 2-chloro-3-formylbenzo[1,8]naphthyridines 3a-c has been achieved rapidly in good yield via the Vilsmeier-Haack cyclisation of N-(4-methylquinolin-2yl) acetamide 2a-d. The precursors N-(4-methylquinolin-2-yl) acetamide derivatives were effectively prepared in a single step from 2-aminoquinoline and acetic anhydride in presence of Amberlite-120A cation exchange catalyst under microwave irradiation. Condensation of 3a-d, with thioglycolic acid under microwave irradiation using anhydrous potassium carbonate as catalyst afforded thieno[2,3-b]benzo[1,8]naphthyridine-2-carboxylic acids (TBNCS) 4a-g. Elemental analysis, IR, H-1 NMR, and mass spectral studies were used to characterize these compounds. The interaction of thieno[2,3-b] benzo[1,8]naphthyridine-2-carboxylic acid (TBNC)(4a) with CT-DNA was studied by UV-Vis, viscosity as well as thermal denaturation methods. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. Binding parameters, determined from spectrophotometeric measurements indicated a binding constant of 1.8 X 10(6) M-1. The thieno[2,3-b]benzo[1,8] naphthyridine-2-carboxylic acid (4a) increases the viscosity of sonicated rod- like DNA fragments. The binding of TBNC to DNA increased the melting temperature by about 4 degrees C. DNA interaction studies suggest that (4a) binds to calf thymus DNA (CT-DNA).
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem