Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. In an article, author is Chaitanya, M. V. S. R. K., once mentioned the application of 13922-41-3, Name is Naphthalen-1-ylboronic acid. Now introduce a scientific discovery about this category, Application In Synthesis of Naphthalen-1-ylboronic acid.
The reaction of naphthyridine hydrazide (4) with each of the different beta-keto esters like ethyl 2-chloroacetoacetate (5), ethyl benzoylacetate (6) and ethyl 4-chloroacetoacetate (7) and with ethoxymethylenemalonic ester (8), independently, in ethanol, resulted in the formation of condensed products 2-chloro-3-[4-oxo-1,4-dihydro-[1,8] naphthyridine-3-carbonyl hydrazono]-butyric acid ethyl ester (9), 3-[(4-oxo-1,4-dihydro-[1,8] naphthyridine-3-carbonyl)-hydrazono]-3-phenyl propionic acid ethyl ester (10), 4-chloro-3-[(4-oxo-1,4-dihydro-[1,8] naphthyridine-3-carbonyl)-hydrazono]-butyric acid ethyl ester (11) and 2-[N-(6-bromo-4-oxo-1,4-diydro-[1,8] naphtyiridine-3-carbonyl-hydrazinomethylene)-malonic acid diethyl ester] (12) respectively. Each of these on heating with diphenyl ether yielded the corresponding cyclized products 3-(4-chloro-3-methyl-5-oxo-4,5-dihydro-pyrazole-1-carbonyl)-1H-[1,8] naphthyridin-4-one (13), 3-(5-oxo-3-phenyl-4,5-dihydro-pyrazole-1-carbonyl)-1H-[1,8] naphthyridine-4-one (14), 3-(3-chloromethyl-5-oxo-4,5-dihydropyrazole-1-carbonyl)-1H-[1,8] naphthyridine-4-one (15) and 3-(4-chloro-3-methyl-5-oxo-4, 5-dihydropyrazole-1-carbonyl)-1H-[1, 8] naphthyridin-4-one (16). Alternatively, treatment of naphthyridine hydrazide (4) with each of the beta-keto esters 5,6 & 7 and with EMME (8) directly in diphenylether at 250 degrees as one-pot reaction, gave the final products 13,14,15 & 16 in good yields.
Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Welcome to check out more blogs about 13922-41-3, in my other articles. Application In Synthesis of Naphthalen-1-ylboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem