Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 106-49-0, Name is p-Toluidine, molecular formula is C7H9N, Application In Synthesis of p-Toluidine, belongs to naphthyridine compound, is a common compound. In a patnet, author is Yang, Shu-Ting, once mentioned the new application about 106-49-0.
The direct reaction between 2,7-bis(2-pyridinyl)-1,8-naphthyridine (bpnp) and Pd(CH3COO)(2) in CF3COOH yields the new dinuclear palladium(II) complex [Pd-2(bpnp)(mu-OH)(CF3CO2)(2)](CF3CO2) (1). Similarly, substitution of Pd(CH3CN)(4)(BF4)(2) with bpnp in DMF gives [Pd-2(bpnp)(mu-OH)(DMF)(2)](BF4)(3) (2). Treatment of 1 or 2 with Cl- readily provide the chloro-substituted species [Pd(bpnp)(mu-OH)(Cl)(2)](+). All complexes were characterized by spectroscopic methods, and the structure of 2 was further confirmed by X-ray crystallography. Complex 1 is an efficient catalyst for the reduction of aromatic nitro compounds leading to the corresponding aniline derivatives under atmospheric pressure of hydrogen at 50 degrees C. The mechanistic pathway of the catalysis is investigated. From the reaction pathway, it is suggested that a facile condensation of nitroso and hydroxylamine intermediates is enabled by the dipalladium system and the desired transformation proceeds smoothly under mild reaction conditions to yield the reduced product.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 106-49-0, in my other articles. Application In Synthesis of p-Toluidine.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem