Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 98796-51-1, Name is 5′-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], molecular formula is C40H49N4O8P, SDS of cas: 98796-51-1, belongs to naphthyridine compound, is a common compound. In a patnet, author is Liu, Hongtao, once mentioned the new application about 98796-51-1.
The apical sodium dependent bile acid transporter (ASBT) is the main transporter to promote re-absorption of bile acids from the intestinal tract into the enterohepatic circulation. Inhibition of ASBT could increase the excretion of bile acids, thus increasing bile acid synthesis and consequently cholesterol consumption. Therefore, ASBT is an attractive target for developing new cholesterol-lowering drugs. In this report, a series of 1-(2,4-bifluoropheny1)-7-dialkylamino-1,8-naphthyridine-3-carboxamides were designed as inhibitors of ASBT. Most of them demonstrated potency against ASBT transport of bile acids. In particular, compound 4a(1) was found to have the best activity, resulting in 80.1% inhibition of ASBT at 10 mu mol/L. (C) 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Welcome to check out more blogs about 98796-51-1, in my other articles. SDS of cas: 98796-51-1.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem