Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 3491-12-1, Name is 4-[4-(4-aminophenoxy)phenoxy]aniline, SMILES is NC1=CC=C(OC2=CC=C(OC3=CC=C(N)C=C3)C=C2)C=C1, belongs to naphthyridine compound. In a document, author is Kobayashi, Kazuhiro, introduce the new discover, Application In Synthesis of 4-[4-(4-aminophenoxy)phenoxy]aniline.
The addition of secondary amines to (2-chloropyridin-3-yl)(2-isothiocyanatophenyl)methanone, derived from 2-chloropyridine and N-(2-formylphenyl)formamide, followed by treatment of the resulting thiourea intermediates with sodium hydride has proven to provide a method for the synthesis of N,N-dialky1-5-oxobenzo[b][1,8]naphthyridine-10 (5H)-carbothioamides. Similarly, N,N-dialkyl-5-oxobenzo[b][1,7]naphthyridine-10(5H)-carbothioamides and N,N-dialkyl-10-oxobenzo[b][1,6]naphthyridine-5(10H)-carbothioamides can be prepared from the respective (chloropyridinyl)(2-isothiocyanatophenyl)methanones.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 3491-12-1, in my other articles. Application In Synthesis of 4-[4-(4-aminophenoxy)phenoxy]aniline.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem