New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 106-49-0, Name is p-Toluidine, SMILES is NC1=CC=C(C)C=C1, belongs to naphthyridine compound. In a document, author is Wang, Dao-Lin, introduce the new discover, COA of Formula: https://www.ambeed.com/products/106-49-0.html.
An efficient method for the synthesis of novel benzo[b]pyrimido[4′,5′:5,4]thieno[2,3-e]41,61naphthyridine-8-one derivatives via Pictet-Spengler cyclization is reported. The reaction of 4-(3-aminopyrimido[4,5-d]thieno-2-yl)quinoline-2-ones, which could be obtained from Thorpe -Ziegler isomerization of 4-bromomethylquinoline-2-ones and 5-cyano-1,6-dihydro-4-methyl-2-phenyl-6-thioxopyrimidine, with aromatic aldehydes in the presence of BF3.OEt2 gives pyrimidothieno[1,6]naphthyridines in good yields. (C)2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 106-49-0, in my other articles. COA of Formula: https://www.ambeed.com/products/106-49-0.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem