New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis .6165-69-1, Name is 3-Thiopheneboronic acid, SMILES is OB(C1=CSC=C1)O, belongs to naphthyridine compound. In a document, author is Abdel-Wadood, Fatma K., introduce the new discover, Recommanded Product: 3-Thiopheneboronic acid.
3-Cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)-thione (3a) and 3-cyano-6-methyl-4-(2′-thienyl)-5,6,7,8-tetrahydro[1,6]naphthyridine-2(1H)-thione (3b) were reacted with alpha-halo compounds to give the intermediates 4a-j which upon refluxing in ethanolic sodium ethoxide afforded the thieno[2,3-b][1,6]naphthyridine derivatives 5a-l. Further annellation of pyridine and pyrimidine rings to the remaining free bond of the fused thiophene ring was achieved, providing tetrahydro-pyrido[2′,3′:4,5]- and -pyrimido[4′,5′:4,5]-thieno[2,3-b][1,6]naphthyridines. Some of the synthesised compounds were screened against different strains of bacteria.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. I hope my blog about 6165-69-1 is helpful to your research. Recommanded Product: 3-Thiopheneboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem