New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis .13822-56-5, Name is 3-(Trimethoxysilyl)propan-1-amine, SMILES is NCCC[Si](OC)(OC)OC, belongs to naphthyridine compound. In a document, author is Kulakov, Ivan V., introduce the new discover, Recommanded Product: 3-(Trimethoxysilyl)propan-1-amine.
A one-pot method for obtaining novel thieno[3,2c][ 1,7] naphthyridine derivatives based on the reaction of 3-amino-4( thien-2-yl)pyridin-2(1H)-one with aromatic aldehydes in 80% phosphoric acid at 130 degrees C has been developed. The formation of the thieno[3,2-c][1,7] naphthyridine ring was due to the intermediate generation of the corresponding azomethine, which underwent intramolecular cyclization with electrophilic attack of the beta-carbon atom of the thiophene core under Pictet-Spengler conditions. The isolated 5,7-dihydrothieno[ 3,2-c][1,7]naphthyridin-4(3H)-ones underwent oxidative aromatization in air to give thieno[3,2-c][1,7] naphthyridin-6(7H)ones. A two-step synthesis of thieno[3,2-c][1,7] naphthyridines involving the isolation of the intermediate imine did not lead to a significant increase in the product yield.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 13822-56-5, in my other articles. Recommanded Product: 3-(Trimethoxysilyl)propan-1-amine.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem