New research progress on 13922-41-3 in 2021. 13922-41-3, Name is Naphthalen-1-ylboronic acid, molecular formula is C10H9BO2, Name: Naphthalen-1-ylboronic acid, SMILES is C1=CC=C2C(=C1)C(=CC=C2)B(O)O belongs to naphthyridine compound, is a common compound. In a patnet, author is Goerlitzer, K., once mentioned the new application about 13922-41-3.
The 2,5-dichlorobenzo[c][2,7]naphthyridine 6 was synthesized starting from the 2-pyridone 1 in four or five steps, respectively. The 5-yl amine 7 and the 2,5-diyl amines 8 and 9 were isolated by the reaction of compound 6 with the novaldiamine base. Starting with the reaction of the 6-chloropyridine 3 with the novaldiamine base to yield the 6-aminopyridine 11, the 2-yl amine 13, isomeric to 7, was obtained. Compounds 7-13 were tested for in vitro antimalarial activity using a chloroquine sensitive and resistant Plasmodium falciparum strain. The highest activity was shown by 8 with IC50 values of 90 nM and 190 nM, respectively.
These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 13922-41-3, Name: Naphthalen-1-ylboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem