New discoveries in chemical research and development in 2021. 99-09-2, Name is 3-Nitroaniline, molecular formula is C6H6N2O2, Formula: https://www.ambeed.com/products/99-09-2.html, belongs to naphthyridine compound, is a common compound. In a patnet, author is Catalano, Raffaella, once mentioned the new application about 99-09-2.
It is well recognized that the non-canonical DNA structures known as G-quadruplexes (G4s) have a potential anticancer significance and several compounds have been discovered and evaluated as promising G4 binders with anticancer activity. Here, starting from a promising hit with an indolo-naphthyridine scaffold, a small series of five indolo-naphthyridine based derivatives have been designed and evaluated as G4-targeting compounds. FRET biophysical studies were performed on multiple DNA G4 structures, leading to the identification of a multi-target G4 stabilizer with a slight preference for the c-KIT1 and a good G4 over duplex selectivity. The good affinity of this compound against c-KIT1 G4 was also confirmed by SPR and MST experiments, while biological assays revealed its cytotoxic activity on tumour cells. Finally, Molecular Dynamics simulations helped to elucidate the stabilization effect of the selected compound against the c-KIT1 G4. (C) 2019 Elsevier Masson SAS. All rights reserved.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 99-09-2. Formula: https://www.ambeed.com/products/99-09-2.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem