New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 92-70-6, Name is 3-Hydroxy-2-naphthoic acid, SMILES is C1=C2C(=CC(=C1C(O)=O)O)C=CC=C2, belongs to naphthyridine compound. In a document, author is Li, Jianjun, introduce the new discover, Safety of 3-Hydroxy-2-naphthoic acid.
A Co(OAc)(2)-catalyzed trifluoromethylation and subsequent C(3) -selective arylation of 2-(propargylamino)-pyridines has been developed. A new 6-endo-dig cyclization involving an unprecedented C(3) selective arylation of the pyridines instead of a commonly observed 5-exo-dig cyclization with N is realized. Moreover, the study presents the first case of the installation of a trifluoromethyl group into electron deficient azaarenes. The process delivers an efficient cascade approach to new trifluoromethylated 1,8-naphthyridine structures with a broad substrate scope.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 92-70-6, Safety of 3-Hydroxy-2-naphthoic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem