New research progress on 132-64-9 in 2021. 132-64-9, Name is Dibenzo[b,d]furan, molecular formula is C12H8O, Application In Synthesis of Dibenzo[b,d]furan, SMILES is C12=CC=CC=C1C3=CC=CC=C3O2 belongs to naphthyridine compound, is a common compound. In a patnet, author is Dohno, Chikara, once mentioned the new application about 132-64-9.
DNA molecular glue is a small synthetic ligand that can adhere two single-stranded DNAs that do not spontaneously hybridize with each other. For reversible control of DNA hybridization by an external light stimulus, we have developed a photoswitchable molecular glue for DNA. The photoswitchable molecular glue, NCDA, consists of two guanine-recognizing naphthyridine moieties connected with a photochromic azobenzene unit. Azobenzene undergoes a reversible cis/trans isomerization by photoirradiation, which changes the relative orientations and positions of the naphthyridine moieties, resulting into photoswitching of NCDA binding to the DNA containing GG-mismatch. NCDA in the cis configuration binds to a GG-mismatch sequence and induces the formation of the DNA duplex. Using the photoswitchable binding property of NCDA, the hybridization event of two natural unmodified DNAs can be reversibly controlled by an external light stimulus.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 132-64-9. Application In Synthesis of Dibenzo[b,d]furan.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem