Chemical Research Letters, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. catalysts provide a surface to which reactants bind. In an article, author is Wagner, E., once mentioned the application of 709-63-7, Name is 4-(Trifluoromethyl)acetophenone. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/709-63-7.html.
An attempt to rearrange pyrrolo[3,4-c]pyridine-1,3-diones to the 2,7-naphthyridine ring under the conditions, described in only one report [I], gave compounds 7-9, but did not yield the expected 2,7- or 2,6-naphthyridine isomers. Important for the synthesis of the naphthyridine ring from pyrrolo[3,4-c]pyridine was that, of the two possible isomers, only 2,7- not 2,6-naphthyridine was obtained. Ethyl (4-R’-1,3-dioxo-6-phenyl-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)acetate (5, 6, 10) treated with sodium ethoxide was rearranged by the Claisen-Dieckmann reaction to ethyl 4-hydroxy-8-R’-1-oxo-6-phenyl-1,2-dihydro-2,7-naphthyridine-3-carboxylate (13,14), where R’=methyl or ethoxy. The structures of the new compounds were confirmed by elemental analysis and NMR and IR spectra. The structure of 14 was also determined by X-ray crystallography to prove the presence of 2,7-naphthyridine isomer. The in vitro anticancer activities of the final 2,7-naphthyridines were tested at the US NCI (Bethesda, MD). Compound 13 exhibited cytostatic activity in vitro.
The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 709-63-7. Formula: https://www.ambeed.com/products/709-63-7.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem