New discoveries in chemical research and development in 2021. 1631-25-0, Name is N-Cyclohexylmaleimide, molecular formula is C10H13NO2, Safety of N-Cyclohexylmaleimide, belongs to naphthyridine compound, is a common compound. In a patnet, author is Mahesh, Radhakrishnan, once mentioned the new application about 1631-25-0.
A series of novel 1,8-naphthyridine-3-carboxamides as 5-HT3 receptor antagonists were synthesized with an intention to explore the antidepressant activity of these compounds. The title carboxamides were designed using ligand-based approach keeping in consideration the structural requirement of the pharmacophore of 5-HT3 receptor antagonists. The compounds were synthesized using appropriate synthetic route from the starting material nicotinamide. 5-HT3 receptor antagonism of all the compounds, which was denoted in the form of pA(2) value, was determined in longitudinal muscle myenteric plexus preparation from guinea-pig ileum against 5-HT3 agonist, 2-methyl-5-HT. Compound 8g (2-methoxy-1, 8-naphthyridin-3-yl) (2-methoxy phenyl piperazine-1-yl) methanone was identified as the most active compound, which expressed a pA(2) value of 7.67. The antidepressant activity of all the compounds was examined in mice model of forced swim test (FST); importantly, none of the compounds was found to cause any significant changes in the locomotor activity of mice at the tested dose levels. In FST, the compounds with considerably higher pA(2) value exhibited promising antidepressant-like activity, whereas compounds with lower pA(2) value did not show antidepressant-like activity as compared to the control group.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 1631-25-0. Safety of N-Cyclohexylmaleimide.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem