Chemical Research Letters, May 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, and research on the structure and performance of functional materials. In an article, author is Naik, Tangali R. Ravikumar, once mentioned the application of 573-17-1, Name is 9-Bromophenanthrene. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/573-17-1.html.
The microwave-enhanced synthesis of 2-chloro-3-formylbenzo[1,8]naphthyridines 3a-c has been achieved rapidly in good yield via the Vilsmeier-Haack cyclisation of N-(4-methylquinolin-2yl) acetamide 2a-d. The precursors N-(4-methylquinolin-2-yl) acetamide derivatives were effectively prepared in a single step from 2-aminoquinoline and acetic anhydride in presence of Amberlite-120A cation exchange catalyst under microwave irradiation. Condensation of 3a-d, with thioglycolic acid under microwave irradiation using anhydrous potassium carbonate as catalyst afforded thieno[2,3-b]benzo[1,8]naphthyridine-2-carboxylic acids (TBNCS) 4a-g. Elemental analysis, IR, H-1 NMR, and mass spectral studies were used to characterize these compounds. The interaction of thieno[2,3-b] benzo[1,8]naphthyridine-2-carboxylic acid (TBNC)(4a) with CT-DNA was studied by UV-Vis, viscosity as well as thermal denaturation methods. On binding to DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. Binding parameters, determined from spectrophotometeric measurements indicated a binding constant of 1.8 X 10(6) M-1. The thieno[2,3-b]benzo[1,8] naphthyridine-2-carboxylic acid (4a) increases the viscosity of sonicated rod- like DNA fragments. The binding of TBNC to DNA increased the melting temperature by about 4 degrees C. DNA interaction studies suggest that (4a) binds to calf thymus DNA (CT-DNA).
The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 573-17-1. Computed Properties of https://www.ambeed.com/products/573-17-1.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem