New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis .23814-12-2, Name is 1H-Benzo[d][1,2,3]triazole-5-carboxylic acid, SMILES is O=C(C1=CC=C(NN=N2)C2=C1)O, belongs to naphthyridine compound. In a document, author is Sriram, Dharmarajan, introduce the new discover, Product Details of 23814-12-2.
Fifty-one 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acids were synthesized and evaluated for antimycobacterial in vitro and in vivo against Mycobacterium tuberculosis H37Rv (MTB), multi-drug-resistant Mycobacterium tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC2) and also tested for the ability to inhibit the supercoiling activity of DNA gyrase from M. smegmatis. Among the synthesized compounds, 1-tert-butyl-1,4-dihydro-7-(4,4-dimethyloxazolidin-3-yl)-6-nitro-4-oxo-1,8-naphthyridine-3-carboxylic acid (10q) was found to be the most active compound in vitro with an MIC of 0.1 mu M against MTB and MDR-TB and was 3 and 455 times more potent than isoniazid against MTB and MDR-TB, respectively. In the in vivo animal model 10q decreased the bacterial load in lung and spleen tissues with 2.39 and 3.89-log 10protections respectively at the dose of 50 mg/kg body weight.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 23814-12-2, in my other articles. Product Details of 23814-12-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem