New discoveries in chemical research and development in 2021. 82-76-8, Name is 8-(Phenylamino)naphthalene-1-sulfonic acid, molecular formula is C16H13NO3S, Quality Control of 8-(Phenylamino)naphthalene-1-sulfonic acid, belongs to naphthyridine compound, is a common compound. In a patnet, author is Boynton, Adam N., once mentioned the new application about 82-76-8.
[Ru(bpy)(2)(BNIQ)](2+) (BNIQ= Benzor[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site IDNAKRu] compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)(2)(2+) and [Fe(CN)(6)](3-) implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model and predict the effects of solvation within porous materials, I hope to 82-76-8 help many people in the next few years. Quality Control of 8-(Phenylamino)naphthalene-1-sulfonic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem