New Advances in Chemical Research, April 2021.The transformation of simple hydrocarbons into more complex has revolutionised modern synthetic chemistry. This type of reactivity has quickly become one of the cornerstones of modern catalysis .3491-12-1, Name is 4-[4-(4-aminophenoxy)phenoxy]aniline, SMILES is NC1=CC=C(OC2=CC=C(OC3=CC=C(N)C=C3)C=C2)C=C1, belongs to naphthyridine compound. In a document, author is Kobayashi, Kazuhiro, introduce the new discover, Application In Synthesis of 4-[4-(4-aminophenoxy)phenoxy]aniline.
The addition of secondary amines to (2-chloropyridin-3-yl)(2-isothiocyanatophenyl)methanone, derived from 2-chloropyridine and N-(2-formylphenyl)formamide, followed by treatment of the resulting thiourea intermediates with sodium hydride has proven to provide a method for the synthesis of N,N-dialky1-5-oxobenzo[b][1,8]naphthyridine-10 (5H)-carbothioamides. Similarly, N,N-dialkyl-5-oxobenzo[b][1,7]naphthyridine-10(5H)-carbothioamides and N,N-dialkyl-10-oxobenzo[b][1,6]naphthyridine-5(10H)-carbothioamides can be prepared from the respective (chloropyridinyl)(2-isothiocyanatophenyl)methanones.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.Welcome to check out more blogs about 3491-12-1, in my other articles. Application In Synthesis of 4-[4-(4-aminophenoxy)phenoxy]aniline.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem