New research progress on 1118-61-2 in 2021. 1118-61-2, Name is 3-Aminocrotononitrile, molecular formula is C4H6N2, Product Details of 1118-61-2, SMILES is CC(N)=CC#N belongs to naphthyridine compound, is a common compound. In a patnet, author is Ye, Pengqing, once mentioned the new application about 1118-61-2.
We report herein a rare-earth-metal-catalyzed insertion of a 2-pyridine C(sp(2))-H bond into an intramolecular unactivated vinyl bond. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodology is also used to construct other nitrogen-containing compounds such as naphthyridine derivatives. A plausible mechanism for the formation of azaindolines involving initial C-H bond activation by the lanthanide complex followed by C=C insertion into a Ln-C bond to form an alkyl lanthanide species that subsequently undergoes cyclization is proposed.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 1118-61-2. Product Details of 1118-61-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem