New discoveries in chemical research and development in 2021. 1118-61-2, Name is 3-Aminocrotononitrile, molecular formula is C4H6N2, Formula: https://www.ambeed.com/products/1118-61-2.html, belongs to naphthyridine compound, is a common compound. In a patnet, author is Abdelrazek, Fathy M., once mentioned the new application about 1118-61-2.
2-(1-Aryl-ethylidene)-malononitriles 1a-d undergo self dimerization in ethanol catalyzed by sodium ethoxide to afford 2[4.6-diaryl-3-cyano-6-methyl-5,6-dihydropyridin-2(1H)-ylidene]-malononitrile derivatives 3a-d, respectively. The structure of the dimer was elucidated by X-ray crystallography and a plausible mechanism for its formation is depicted. Compound 3a couples with arene diazonium salts 4a-d to afford the hydrazo derivatives 5a-d; and reacts with hydrazine hydrate and phenylhydrazine 6a,b to afford the pyrazolo[3,4-h][1,6]naphthyridine derivatives7a,b; and with urea and thiourea 8a,b to afford the pyrimido[4,5-h][1,6]naphthyridine derivatives 9a,b, respectively.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. In my other articles, you can also check out more blogs about 1118-61-2. Formula: https://www.ambeed.com/products/1118-61-2.html.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem