New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Gopalsamy, Ariamala, once mentioned the application of 99-09-2, Name is 3-Nitroaniline, molecular formula is C6H6N2O2. Now introduce a scientific discovery about this category, Recommanded Product: 99-09-2.
An efficient synthesis of dibenzo[c,f]-2,7-naphthyridine ring system through design of experiments
The dibenzo[c,f]-2,7-naphthyridine ring system was found to be of biological interest, but had limited synthetic accessibility. The initial compound of interest, 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine, was obtained in < 25% yield by reacting 4-chloro-6,7-dimethoxy-quinoline-3-carbonitrile with 2-methyl-benzene-1,3-diamine. A reliable high-yielding procedure was identified through the use of design of experiments (DOE). The effects of stoichiometry of reagents, catalyst, and temperature were explored in this study. The DOE optimization suggested temperatures higher than the boiling point of our solvent. Hence, microwave heating was used, resulting in 80% yield of the desired product. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In my other articles, you can also check out more blogs about 99-09-2. Recommanded Product: 99-09-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem