The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6165-69-1, Name is 3-Thiopheneboronic acid, SMILES is OB(C1=CSC=C1)O, in an article , author is Plodek, Alois, once mentioned of 6165-69-1, Recommanded Product: 6165-69-1.
Synthesis of the Azaoxoaporphine Alkaloid Sampangine and Ascididemin-Type Pyridoacridines through TMPMgCl center dot LiCl-Mediated Ring Closure
We report the synthesis of the azaoxoaporphine alkaloid sampangine (4) and a series of ring A analogues and isomers of the marine pyridoacridine alkaloid ascididemin (2). This approach starts from readily available 1-bromo[2,7] naphthyridine (12) or 4-bromobenzo[c][2,7] naphthyridine (5), and the ring A scaffold bearing an ester moiety is introduced by a Suzuki or Negishi cross-coupling reaction. The final cyclization step was achieved through a directed remote ring metallation with the Knochel-Hauser base (TMPMgCl center dot LiCl; TMP = 2,2,6,6-tetramethylpiperidinyl), followed by intramolecular trapping of the ester group.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem