One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 6165-69-1, Name is 3-Thiopheneboronic acid, formurla is C4H5BO2S. In a document, author is Daw, Prosenjit, introducing its new discovery. HPLC of Formula: C4H5BO2S.
Cyclometalations on the Imidazo[1,2-a][1,8]naphthyridine Framework
Cyclometalation on the substituted imidazo[1,2-a][1,8]naphthyridine platform involves either the C-3-aryl or C-4′-aryl ortho carbon and the imidazo nitrogen N-3′. The higher donor strength of the imidazo nitrogen in comparison to that of the naphthyridine nitrogen aids regioselective orthometalation at the C-3/C-4′-aryl ring with Cp*Ir-III (Cp* = eta(5)-pentamethylcyclopentadienyl). A longer reaction time led to double cyclometalations at C-3-aryl and imidazo C-5′-H, creating six- and five-membered metallacycles on a single skeleton. Mixed-metal Ir/Sn compounds are accessed by insertion of SnCl2 into the Ir-Cl bond. Pd(OAc)(2) afforded an acetate-bridged dinuclear ortho-metalated product involving the C-3-aryl unit. Metalation at the imidazo carbon (C-5′) was achieved via an oxidative route in the reaction of the bromo derivative with the Pd(0) precursor Pd-2(dba)(3) (dba = dibenzylideneacetone). Regioselective C-H/Br activation on a rigid and planar imidazonaphthyridine platform is described in this work.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem