Synthetic Route of 23814-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 23814-12-2, Name is 1H-Benzo[d][1,2,3]triazole-5-carboxylic acid, SMILES is O=C(C1=CC=C(NN=N2)C2=C1)O, belongs to naphthyridines compound. In a article, author is Plodek, Alois, introduce new discover of the category.
Synthesis of the Azaoxoaporphine Alkaloid Sampangine and Ascididemin-Type Pyridoacridines through TMPMgCl center dot LiCl-Mediated Ring Closure
We report the synthesis of the azaoxoaporphine alkaloid sampangine (4) and a series of ring A analogues and isomers of the marine pyridoacridine alkaloid ascididemin (2). This approach starts from readily available 1-bromo[2,7] naphthyridine (12) or 4-bromobenzo[c][2,7] naphthyridine (5), and the ring A scaffold bearing an ester moiety is introduced by a Suzuki or Negishi cross-coupling reaction. The final cyclization step was achieved through a directed remote ring metallation with the Knochel-Hauser base (TMPMgCl center dot LiCl; TMP = 2,2,6,6-tetramethylpiperidinyl), followed by intramolecular trapping of the ester group.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem