Chemistry is an experimental science, COA of Formula: C12H8O, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 132-64-9, Name is Dibenzo[b,d]furan, molecular formula is C12H8O, belongs to naphthyridines compound. In a document, author is Mensaha, Alfred Addo.
1,8-Naphthyridine Based Artificial Receptors for Selective Monosaccharide Binding in Water
1,8-Naphthyridine based bi-bracchial macrocyclic 2 and cage-type macrobicyclic receptor 3 bind monosaccharides in water under physiologically relevant conditions through a combination of hydrophobic, electrostatic and hydrogen bonding interactions. The dissociation constants (K-d) for the complexes between 1,8-naphthyridine receptors 1-3 with a variety of neutral and negatively charged monosaccharides in water were determined by fluorimetric and UV/vis titration. The observed values are in the range from similar to 0.3 to >= 10 mM, and are similar to the K-d reported for lectin/monosaccharide complexes. Among the monosaccharide substrates tested, receptor 2 showed the strongest binding affinity for sialic acid (K-d = similar to 0.3 mM), a monosaccharide that plays many important roles in a wide variety of physiological and pathological processes. Interestingly, receptors 2 and 3 display the ability to discriminate between closely related monosaccharide substrates by opposite variation of the fluorescence emission intensity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 132-64-9, in my other articles. COA of Formula: C12H8O.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem