Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 13822-56-5, Name is 3-(Trimethoxysilyl)propan-1-amine, molecular formula is , belongs to naphthyridines compound. In a document, author is Aljamal, Jalal A., Name: 3-(Trimethoxysilyl)propan-1-amine.
Antilipolytic effects of 1,8-naphthyridine derivatives beta-adrenoceptor antagonists in rat white adipocytes
The rat fat cell beta-adrenoceptors were investigated by studying the effects of new 1,8-naphthyridine derivatives synthesized starting from 7-amino-2-chloro-3-phenyl-1,8- naphthyridine on lipolysis induced by isoprenaline, and alprenolol. Lipolysis induced by isoprenaline agonist was competitively antagonized by the 1,8-naphthyridine analogue with a 7-hydroxy-2-(4′-methoxybenzylamine)-6-nitro-3-phenyl substituent designated as 3. In contrast, 10, 50, and 100 mu m of 7-methoxy and 7-ethoxy derivatives did not modify the concentration- response curve of isoprenaline. A rightward shift of the curve was, however, observed with 50 mu m of a 7-methoxy-2-(4 methoxybenzylamine)-6-amino-3-phenyl substituent designated as 10. The selective beta 1-AR antagonist, 7-hydroxy-4-morpholinomethyl-2-piperazino-1,8-naphthyrid ine slightly reduced isoprenaline- induced lipolysis only at high doses. Alprenolol-mediated lipolytic effect was antagonized by derivative 3, 10 and the selective beta 3-AR antagonist SR 59,230A, but resistant to the selective beta 1-AR antagonist 7-hydroxy-4-morpholinomethyl- -2-piperazino-1,8-naphthyridine. The results provide preliminary pharmacological evidence for the antilipolytic effect of the newly synthesized 1,8-naphthyridine derivatives on rat fat cells. The analogues designated as 3 and 10 were the most potent antagonists of this series.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13822-56-5, in my other articles. Name: 3-(Trimethoxysilyl)propan-1-amine.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem