Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.91-76-9, Name is 2,4-Diamino-6-phenyl-1,3,5-triazine, SMILES is NC1=NC(C2=CC=CC=C2)=NC(N)=N1, belongs to naphthyridines compound. In a document, author is Pan, Jiafeng, introduce the new discover, COA of Formula: C9H9N5.
Label-free and highly sensitive fluorescence detection of lead(ii) based on DNAzyme and exonuclease III-assisted cascade signal amplification
Routine detection of trace amounts of Pb2+ is of significant importance because it poses severe risks to human health and the environment. In this paper, a novel label-free fluorescence platform for the sensitive detection of Pb2+ has been successfully constructed by using Pb2+-specific 8-17 DNAzyme as the molecular recognition element, 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) as the signal reporter, and exonuclease III (Exo III) as the signal amplifier. A good linearity between the fluorescence intensity and the logarithm of Pb2+ concentration was obtained in the range from 100 pM to 10 M with a correlation coefficient (R-2) of 0.99. The sensing system exhibited ultrasensitivity towards Pb2+ at low concentration (50 pM) without any labeling, modification, immobilization, or washing procedure. Besides, the proposed method was also highly selective for Pb2+ against other metal ions. This biosensor was robust and can be applied for the determination of Pb2+ in complex samples with desired recovery and good accuracy. With the successful demonstration of Pb2+ detection, the label-free biosensor can be readily expanded to monitor other targets in a simple, cost-effective, and ultrasensitive way by replacing the target-specific molecular recognition elements.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 91-76-9. COA of Formula: C9H9N5.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem