Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: 3-Chlorophenylboronic acid, 63503-60-6, Name is 3-Chlorophenylboronic acid, molecular formula is C6H6BClO2, belongs to naphthyridines compound. In a document, author is Nam, TG, introduce the new discover.
Regioselective addition of n-alkyllithiums to alpha,alpha ‘-disubstituted-1,8-naphthyridines: Synthesis of 6-amino-3-pyridinol analogs of alpha-tocopherol
n-Alkyllithiums were added to alpha,alpha’-disubstituted-1,8-naphthyridines in non-polar solvents Such as Et2O-hexane mixtures. In polar solvents such as THF, alkyllithium acts as a base rather than a nucleophile. Regioselective addition was achieved for substrates capable of five-membered cyclic chelation of the (alkyl)lithium reagent. Substrates with a TBS-protected alcohol as the co-chelating moiety afforded the best combination of yield and regioselectivity. This methodology was Successfully employed in the preparation of two 6-amino-3-pyridinol analogs of pentamethyl-chromanol (PMC), an alpha-tocopherol derivative with its isoprenoid side chain truncated to a methyl group.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 63503-60-6. Name: 3-Chlorophenylboronic acid.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem