Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.149022-15-1, Name is 3-Methyl-2-benzothiazolinone hydrazone hydrochloride hydrate(1:1:x), SMILES is CN1/C(SC2=CC=CC=C12)=N/N.[H]Cl.[H]O[H], belongs to naphthyridines compound. In a document, author is Tsuruoka, Ryoji, introduce the new discover, SDS of cas: 149022-15-1.
Asymmetric Synthesis of a 5,6,7,8-Tetrahydro-1,6-naphthyridine Scaffold Leading to Potent Retinoid-Related Orphan Receptor gamma t Inverse Agonist TAK-828F
An asymmetric synthesis of the tetrahydronaphthyridine scaffold of TAIL-828F as a ROR gamma t inverse agonist has been developed. The synthesis features a newly discovered atom-economical protocol for Heck-type vinylation of chloropyridine using ethylene gas, an unprecedented formation of dihydronaphthyridine directly from 2-vinyl-3-acylpyridine mediated by ammonia, and a ruthenium-catalyzed enantioselective transfer hydrogenation as key steps. This represents the first example of the enantioselective synthesis of a 5,6,7,8-tetrahydro-1,6-naphthyridine compound. The new synthesis is also free of chromatography or distillation purification processes and therefore qualifies for extension to large-scale manufacture.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 149022-15-1 is helpful to your research. SDS of cas: 149022-15-1.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem