Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 754-05-2, Name is Trimethyl(vinyl)silane, SMILES is C=C[Si](C)(C)C, in an article , author is Cichero, Elena, once mentioned of 754-05-2, HPLC of Formula: C5H12Si.
CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-,-1,6-and-1,8-naphthyridine derivatives as selective CB2 receptor agonists
Novel classes of CB2 agonists based on 4-oxo1,4- dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine scaffolds have shown high binding affinity toward CB2 receptor and good selectivity over CB1. A computational study of comparative molecular fields analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) was performed, in order to identify the key structural features impacting their binding affinity. The final CoMSIA model resulted to be the more predictive, showing r(ncv)(2) = 0.84, r(cv)(2) = 0.619, SEE=0.369, and r(pred)(2) = 0.75. The study provides useful suggestions for the synthesis of new selective analogues with improved affinity.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 754-05-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H12Si.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem