Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 96-49-1, Name is Ethylene carbonate, molecular formula is C3H4O3, belongs to naphthyridines compound, is a common compound. In a patnet, author is Arepalli, Sateesh Kumar, once mentioned the new application about 96-49-1, Category: naphthyridines.
Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f] [1,7]naphthyrdines
A novel series of twenty 1,3-diphenylbenzo[f][1,7]benzonaphthyrdine derivatives were designed and synthesized through intermolecular imino Diels-Alder reaction. Their in vitro cytotoxic activities were evaluated against six human cancer cell lines (NCIH23, HCT15, NUGC-3, ACHN, PC-3, and MDA-MB-231). Majority of synthesized compounds exhibited significant cytotoxic activities against all tested human cancer cell lines. Among them 4l, 4m, and 4o derivatives exhibited most promising cytotoxic activities. Furthermore these compounds were evaluated against human Topoisomerase II alpha inhibition. Interestingly, the compound 4l exhibited 1.3 and 1.2 times more potent human Topoisomerase II alpha inhibition than the reference drug etoposide in both 100 mu M and 20 mu M concentrations respectively. Molecular docking studies for the compound 4l have also been executed by Sybyl X-2.1 in which it reveals the binding site of the compound 4l with topo II alpha DNA cleavage site where etoposide was situated. The benzo[f][1,7]naphthyridine ring was stacked between the DNA bases of the cleavage site. (C) 2017 Elsevier Ltd. All rights reserved.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 96-49-1. The above is the message from the blog manager. Category: naphthyridines.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem