In an article, author is Kurumurthy, C., once mentioned the application of 38002-45-8, Name is (3-Bromoprop-1-yn-1-yl)trimethylsilane, molecular formula is C6H11BrSi, molecular weight is 191.141, MDL number is MFCD00134460, category is naphthyridines. Now introduce a scientific discovery about this category, Application In Synthesis of (3-Bromoprop-1-yn-1-yl)trimethylsilane.
A facile and single pot strategy for the synthesis of novel naphthyridine derivatives under microwave irradiation conditions using ZnCl2 as catalyst, evaluation of AChE inhibitory activity, and molecular modeling studies
A series of novel naphthyridine derivatives 3 and 4 was prepared from substituted pyridine 2 and ketones using ZnCl2 as catalyst under microwave irradiation conditions. All the compounds were evaluated for AChE inhibitory activity and promising compounds 3d, 3e, 4b, and 4g was identified. Representative compounds 3d and 3e were found to show insignificant THLE-2 liver cell viability/toxicity. The binding mode between X-ray crystal structure of human AChE and compounds was studied using molecular docking method and fitness scores were found to be in good correlation with the activity data.
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Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem